Dextran reduced in boron content, process for producing the...

Details Dextran reduced in boron content, process for producing the... Dextran reduced in boron content, process for producing the...

C - Chemistry, Metallurgy

08

B

C08B 37/02 (2006.01) A61K 31/721 (2006.01)

Patent

CA 2306277

The present invention relates to dextran whose boron content is reduced to a value less than 0.30 µg/g (dry basis) calculated on the basis of boron atom, a process for producing the same, and dextran with which a container is filled in a solution state. Dextran of the present invention is obtained by treating a boron-containing dextran with a lower alcohol, and said dextran has such a characteristic that deposition is inhibited or the deposition rate is drastically reduced when using it in the form of a solution. Therefore, an isotonic sodium chloride solution of said dextran is suitably used as substitute plasma or external perfusate in an operation.

L'invention concerne un dextrane à teneur réduite en bore, inférieure à 0,30 mu g/g en termes d'atome de bore (à l'état sec); elle concerne également un procédé de production de ce dextrane ainsi que ce dextrane lui-même, à l'état de solution, placé dans un contenant. On obtient ce dextrane en traitant un dextrane riche en bore à l'aide d'un alcool inférieur. Ce dextrane est caractérisé en ce qu'il est empêché de se précipiter lorsqu'il est utilisé à l'état de solution, ou en ce qu'il présente un taux de précipitation grandement diminué. Ainsi, puisqu'une solution de ce dextrane, placée par exemple dans une solution saline physiologique, possède une grande stabilité lors de son stockage, on peut l'utiliser en tant que substitut du plasma sanguin ou en tant que fluide de circulation extracorporelle, lors d'opérations.

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