Dhea composition and method

Details Dhea composition and method Dhea composition and method

A - Human Necessities

61

K

A61K 31/5685 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/00 (2006.01) A61K 31/568 (2006.01) A61P 3/00 (2006.01) A61P 5/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2332767

Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation comprises, in solid form, DHEA, at least 85% of which is present as a single polymorph selected from the form I polymorph or the form II polymorph, and at least one pharmaceutical excipient. Methods for making and using such compositions are also disclosed.

L'invention concerne des formulations pharmaceutiques améliorées comprenant de la déhydroépiandrostérone (DHEA) enrichie en polymorphes de formes sélectionnées, destinées à des applications thérapeutiques. Dans une forme d'exécution, cette formulation comprend de la DHEA sous forme solide dont au moins 85 % sont présents sous une même forme de polymorphe sélectionnée entre la forme I et la forme II, et au moins un excipient pharmaceutique. L'invention concerne également des procédés de préparation et d'utilisation de ces compositions.

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