C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/423 (2006.01) A61K 31/506 (2006.01) A61P 11/00 (2006.01) C07D 261/20 (2006.01) C07D 413/14 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2658190
The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various fibrotic and mast cell related diseases such as mastocytosis. The compounds have a general Formula (I) wherein R1-6, X and Y are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
La présente invention concerne une nouvelle classe de composés qui sont capables de moduler le récepteur c-kit et qui, par conséquent, sont utilisables pour le traitement des maladies induites par le c-kit, dont diverses maladies de type fibrose et liées aux mastocytes telles que la mastocytose. Les composés répondent à la formule générale (I) dans laquelle R1-6, X et Y sont définis ici. L'invention concerne en outre des compositions pharmaceutiques, des procédés de traitement des maladies induites par le c-kit, ainsi que des intermédiaires et des procédés utiles pour la préparation des composés de l'invention.
Chen Ning
Hu Essa
Amgen Inc.
Gowling Lafleur Henderson Llp
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