Di-and trisubstituted pyridines and their preparation

Details Di-and trisubstituted pyridines and their preparation Di-and trisubstituted pyridines and their preparation

C - Chemistry, Metallurgy

12

P

C12P 17/12 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2163602

Substituted pyridines of the general formula: Image (I) in which R1 is hydroxyl or chlorine and either: a) X is hydrogen or chlorine, R2 and R3 together are =O, R4 is a group of the formula -OR5 where R5 is hydrogen, C1-C4-alkyl or benzyl; or b) X is hydrogen and R2, R3 and R4 together are =N-NH-; or c) X and R2 are hydrogen and R3 and R4 together are -O-; or d) X and R2 are hydrogen, R3 is hydroxyl and R4 is amino or hydroxyl. The compounds (I) are obtained by subjecting nicotine to microbiological oxidation to give 5-succinoyl-2-pyridone, followed by chemical reactions. They are suitable as intermediates for the preparation of pharmaceutically active compounds.

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