Di-aryl substituted triazole modulators of metabotropic...

Details Di-aryl substituted triazole modulators of metabotropic... Di-aryl substituted triazole modulators of metabotropic...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01)

Patent

CA 2521396

Novel triazole compounds represented by Formula (I): (where A, A1, A2, A3, A4, A5, B, R11, W, X, Y and Z are as defined herein) in which the triazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson~s disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases.

L'invention concerne des composés au triazole de formule (I): ( A, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, B, R?11¿, W, X, Y et Z tels que définis dans la description). Le triazole est à substitution directe, ou par pont, avec i) une fraction hétéroaryle renfermant N adjacent au point de connexion de l'hétéroaryle, et ii) une autre chaîne hétéroaryle ou aryle, avec au moins l'une des chaînes encore substituée par une autre chaîne. Ces composés sont des modulateurs de mGluR5 utiles dans le traitement des troubles psychiatriques et de l'humeur, du type schizophrénie, anxiété, dépression, panique, et trouble bipolaire, ainsi que pour le traitement de la douleur, la maladie de Parkinson, le dysfonctionnement cognitif, l'épilepsie, les troubles du rythme circadien, la toxicomanie, l'abus de drogues, le sevrage de drogues, l'obésité, et autres maladies.

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