Di-lysogangliosides derivatives

Details Di-lysogangliosides derivatives Di-lysogangliosides derivatives

C - Chemistry, Metallurgy

07

H

195/140, 167/199

C07H 5/04 (2006.01) C07H 13/04 (2006.01) C07H 15/10 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2022139

Abstract of the Disclosure N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di- lysogangliosides and N,N'-diacyl-N,N'-di- lysogangliosides, wherein the acyl groups are derived from an aliphatic acid having from 1 to 24 carbon atoms, substituted by one or more polar groups are disclosed. The acyl-di-lysogangliosides of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.

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