Di-n su6' xx, o.sup.3-demethylistamycin a and preparation...

Details Di-n su6' xx, o.sup.3-demethylistamycin a and preparation... Di-n su6' xx, o.sup.3-demethylistamycin a and preparation...

C - Chemistry, Metallurgy

07

H

260/230.52

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1175817

TITLE OF INVENTION Di-N6',O3-demethylistamycin A and preparation thereof ABSTRACT OF THE DISCLOSURE A new istamycin A derivative called di-N6',O3- demethylistamycin A exhibits a high antibacterial activity against various bacteria, particularly Pseudomonas aeruginosa This compound can be prepared by selective acylation of the methylamino group at the 4-position of 1,2',6'-tri-N- protected N4-deglycyl-di-N6',O3-demethylistamycin A with glycine or an N-protected derivative thereof, followed by N-deprotection.

374047

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