Di-substituted oxadiazoles as cxc-chemokine receptor ligands

Details Di-substituted oxadiazoles as cxc-chemokine receptor ligands Di-substituted oxadiazoles as cxc-chemokine receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4245 (2006.01) A61P 19/00 (2006.01) C07D 271/08 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2613607

Disclosed are compounds of the formula (1). and the pharmaceutically acceptable salts thereof. X is N or N+O-, and Y is N or N+O-, provided that at least X or Y is N. The compounds are useful for the treatment of chemokine- mediated diseases such as COPD.

La présente invention se rapporte à des composés représentés par la formule (1) ainsi qu'à des sels pharmaceutiquement acceptables de ces composés. Dans ladite formule X est N ou N+O-, et Y est N ou N+O-, à condition qu'au moins X ou Y soit N. Ces composés s'avèrent utiles pour le traitement des maladies à médiation par des chimiokines, par exemple la broncho-pneumopathie chronique obstructive (PBCO).

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