Di-substituted phenyl compounds

Details Di-substituted phenyl compounds Di-substituted phenyl compounds

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/4427 (2006.01) A61K 31/47 (2006.01) A61P 3/10 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 215/227 (2006.01) C07D 295/02 (2006.01) C07D 407/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2729220

Di-substituted phenyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. The disclosure also relates to methods for treating neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.

L'invention porte sur des composés phényles disubstitués qui sont des inhibiteurs de la phosphodiestérase, sur des procédés, des compositions pharmaceutiques, des préparations pharmaceutiques et l'utilisation pharmaceutique desdits composés dans le traitement de troubles du système nerveux central (SNC) et autres affections pouvant toucher la fonction du SNC chez les mammifères, y compris les êtres humains, L'invention se rapporte également à des procédés destinés au traitement de troubles neurologiques, neurodégénératifs et psychiatriques, y compris, de manière non limitative, ceux qui entraînent des déficits cognitifs et des symptômes schizophréniques.

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