C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/234, 167/242
C07D 277/14 (2006.01) A61K 31/39 (2006.01) A61K 31/425 (2006.01) C07D 277/16 (2006.01) C07D 277/20 (2006.01) C07D 277/34 (2006.01) C07D 277/36 (2006.01) C07D 327/04 (2006.01) C07D 417/06 (2006.01)
Patent
CA 1285572
ABSTRACT OF THE DISCLOSURE This invention provides di-t-butylphenols of formula I: Image I wherein Q is O or NR, where R is hydrogen or C1-C4 alkyl; R1 and R2 are each hydrogen, or when taken together form a bond; and R3 and R4 are each hydrogen, or when taken together are =S, provided that when R1 and R2 taken together are a bond and Q is NH, R3 and R4 may only be hydrogen; and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical formulations comprising as the active ingredient a compound of the general formula Image I wherein Q is O or NR, where R is hydrogen or C1-C4 alkyl; R1 and R2 are each hydrogen, or when taken together form a bond; and R3 and R4 are each hydrogen, or when taken together are =S; or a pharmaceutically acceptable salt thereof, in association with one or more pharmaceutically acceptable carriers or excipients therefor. The foregoing compounds and compositions are useful in treating inflammation, strokes and arthritis in mammals.
515379
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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