Di-t-butylphenyl piperazines as calcium channel blockers

Details Di-t-butylphenyl piperazines as calcium channel blockers Di-t-butylphenyl piperazines as calcium channel blockers

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/495 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2722706

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly N-type or T- type calcium channel activity. Specifically, a series of compounds containing di-t-butylphenyl piperazine derivatives of the general formula (1) is disclosed. The compounds are useful in the treatment of conditions such as pain and other diseases or disorders of hyperexcitability.

L'invention concerne des procédés et des composés efficaces pour améliorer des états pathologiques caractérisés par une activité des canaux calciques indésirable, en particulier une activité des canaux calciques de type T ou de type N. L'invention concerne plus spécifiquement une série de composés contenant des dérivés de di-t-butylphényle piperazine représentés par la formule générale (1). Ces composés conviennent pour le traitement d'états pathologiques tels que la douleur ou d'autres maladies ou des troubles d'hyperexcitabilité.

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