Di-tert-butylphenol compounds useful as anti-inflammatory...

A - Human Necessities – 61 – K

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A61K 31/12 (2006.01)

Patent

CA 2179009

The subject invention involves compositions comprising: (a) a safe and effective amount of a compound having structure (i), wherein n is an integer from 1 to about 5, m is an integer from 0 to about 3, -R is hydrogen or straight or branched chain C1-C3 alkanyl; and (b) a pharmaceutically- acceptable carrier. The subject invention also involves methods for treating diseases characterized by inflammation and/or pain, such as rheumatoid arthritis and osteoarthritis, by administration of a safe and effective amount of this compound to a human or lower animal in need of such treatment.

L'invention porte sur des compositions comprenant: (a) une quantité inoffensive et efficace d'un composé de formule (i) où n est un entier allant de 1 à 5 environ, m est un entier allant de 0 à 3 environ et -R un hydrogène ou un alcanyle C¿1?-C¿3? à chaîne droite ou ramifiée; et (b) un excipient pharmacocompatible. L'invention porte également sur des méthodes de traitement de maladies caractérisées par les inflammations ou douleurs causées par l'arthrite rhumatoïde ou l'ostéoarthrite, par administration à l'homme et à l'animal qui le nécessitent de doses inoffensives et efficaces dudit composé.

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