C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/06 (2006.01) A61K 31/41 (2006.01) C07D 261/04 (2006.01)
Patent
CA 2203138
The subject of the invention relates to compounds having structure (I), wherein: a) each R is independently alkyl having from 1 to about 7 carbon atoms; b) Z is O or N-X; c) X is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, C(O)Y, C(S)Y, and SO2Y; d) Y is selected from R', OR' and NR'2; and e) R' is selected from hydrogen, alkyl having from 1 to about 7 carbon atoms, and phenyl. The subject invention also relates to pharmaceutical compositions comprising the above compounds, and methods of treating inflammation or pain using the compounds.
L'invention porte sur des composés de formule (I) dans laquelle a) chacun des R représente indépendamment un alkyle présentant de 1 à environ 7 atomes de carbone; b) Z représente O ou N-X; c) X est sélectionné parmi hydrogène, alkyle présentant de 1 à environ 7 atomes de carbone, C(O)Y, et SO¿2?Y; d) Y est sélectionné parmi R', OR' et NR'¿2?; et e) R' est sélectionné parmi hydrogène, alkyle présentant de 1 à environ 7 atomes de carbone, et phényle. L'invention porte également sur des préparations pharmaceutiques renfermant lesdits composés et sur des méthodes de traitement d'inflammations ou de douleurs à l'aide desdits composés.
Pikul Stanislaw
Scherz Michael Wiard
Kirby Eades Gale Baker
The Procter & Gamble Company
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