Diacid-substituted heteroaryl derivatives as matrix...

Details Diacid-substituted heteroaryl derivatives as matrix... Diacid-substituted heteroaryl derivatives as matrix...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) C07D 271/10 (2006.01) C07D 277/06 (2006.01) C07D 277/34 (2006.01) C07D 277/56 (2006.01) C07D 285/12 (2006.01) C07D 333/32 (2006.01) C07D 333/70 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2401358

The invention provides dicarboxylic acid-substituted heteroaryl derivatives of the formula G1-(C(R1)R2)n-Q1-B-Q2-(C(R3)R4)m-G2 I or a pharmaceutically acceptable salt thereof, wherein G1, G2, R1, R2, R3, R4, n, m, Q1, Q2, and B are as defined in the specification. The invention compounds are inhibitors of matrix metalloproteinase enzymes, including MMP-13. This invention also provides pharmaceutical compositions and methods of treating diseases mediated by MMP-13, including arthritis, asthma, heart disease, atherosclerosis, and osteoporosis, or a pharmaceutically acceptable salt thereof.

Affiliated with

Also associated with

Rating

Diacid-substituted heteroaryl derivatives as matrix... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diacid-substituted heteroaryl derivatives as matrix..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diacid-substituted heteroaryl derivatives as matrix... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1709119