Diacylethylenediamine compound

Details Diacylethylenediamine compound Diacylethylenediamine compound

C - Chemistry, Metallurgy

07

C

C07C 235/46 (2006.01) A61K 31/343 (2006.01) A61K 31/351 (2006.01) A61K 31/357 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/402 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/421 (2006.01) A61K 31/4245 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/4365 (2006.01) A61K 31/439 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/4535 (2006.01) A61K 3

Patent

CA 2759264

[Problem] A compound which is useful as an anti-obesity agent is provided. [Means for Solution] The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.

L'invention porte sur un composé utile comme agent anti-obésité. Des études ont été effectuées sur des composés qui ont une activité inhibitrice de DGAT1 et sont donc des principes actifs prometteurs pour des compositions pharmaceutiques pour le traitement de l'obésité, du diabète de type II, de la stéatose hépatique et des maladies associées aux maladies mentionnées ci-dessus, et il est confirmé qu'un composé diacyléthylènediamine spécifique a une excellente activité inhibitrice de DGAT1. Le composé diacyléthylènediamine a une activité inhibitrice de DGAT1 et peut être utilisé comme un agent prophylactique et/ou thérapeutique pour l'obésité, le diabète de type II, la stéatose hépatique et les maladies associées aux maladies mentionnées ci-dessus.

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