Diacylglycerol acyltransferase inhibitors

Details Diacylglycerol acyltransferase inhibitors Diacylglycerol acyltransferase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) C07D 211/34 (2006.01) C07D 277/56 (2006.01) C07D 295/155 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2741601

Provided herein are compounds of the formula (I): were R1 is phenyl, R2 is hyrogen, halogen or lower alkyl,X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a-4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of triglicerides, such as, for example, obesity, type I1 diabetes mellitus and metabolic syndrome.

La présente invention concerne des composés de formule (I) : où R1 représente un groupement phényle, R2 représente un atome d'hydrogène ou d'halogène ou un groupement alkyle court, X représente un atome de carbone ou d'azote et R3 représente un groupement isoquinoléine, -amino ou un cycle hétérocycloalkyle comportant entre 4 et 6 chaînons et leurs sels de qualité pharmaceutique, qui ont un effet inhibiteur de DGAT et peuvent donc être employés dans le traitement de pathologies associées à un métabolisme anormal des triglycérides, comme par exemple l'obésité, le diabète sucré de type II et le syndrome métabolique.

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