C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/64 (2006.01) C07H 21/04 (2006.01) C12N 1/18 (2006.01) C12N 9/10 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2585404
Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil biosynthesis in yeast. Each is expected to play a key role in altering the quantity of polyunsaturated fatty acids produced in oils of oleaginous yeasts.
L'invention porte sur des acyltransférases pouvant être utilisés dans la fabrication d'huiles microbiennes enrichies en acides gras oméga dans la levure oléagineuse (par exemple Yarrowia lipolytica). Plus précisément, des gènes codant acyltransférase de diacylglycérol (DGAT1) ont été isolés de Y. lipolytica et Mortierella alpina. Ces gènes codent des enzymes qui participent dans l'étape finale de biosynthèse d'huile dans la levure. Chaque gène joue un rôle clé dans la modification de la quantité d'acides gras poly-insaturés fabriqués dans des huiles de levures oléagineuses.
Xue Zhixiong
Yadav Narendra S.
Zhang Hongxiang
E.i. Du Pont de Nemours And Company
Torys Llp
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