Diacylhydrazine derivatives

Details Diacylhydrazine derivatives Diacylhydrazine derivatives

C - Chemistry, Metallurgy

07

C

C07C 281/06 (2006.01) A61K 31/197 (2006.01) A61K 31/4402 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07C 243/24 (2006.01) C07C 257/14 (2006.01) C07C 279/14 (2006.01) C07C 279/18 (2006.01) C07C 281/02 (2006.01) C07D 213/74 (2006.01) C07D 233/88 (2006.01)

Patent

CA 2379041

Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R1, R2 and R3 have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to combat thromboses, myocardial infarcts, coronary cardiac diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections and restenosis following angioplasty or during pathological processes that are maintained or propagated by angiogenesis.

L'invention concerne des dérivés de diacylhydrazine de la formule (I) dans laquelle X, Y, Z, R?1¿, R?2¿ et R?3¿ ont les significations mentionnées dans la revendication 1, ainsi que leurs sels physiologiquement tolérables ou leurs solvates, qui sont des inhibiteurs d'intégrine et peuvent s'utiliser pour lutter contre des thromboses, l'infarctus du myocarde, des affections cardiaques coronariennes, l'artériosclérose, des inflammations, des tumeurs, l'ostéoporose, des infections et la resténose suite à une angioplastie ou lors de processus pathologiques entretenus ou propagés par angiogenèse.

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