Diagnosing pneumococcal pneumonia

Details Diagnosing pneumococcal pneumonia Diagnosing pneumococcal pneumonia

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/487 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2661210

Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).

L'invention porte sur des compositions et méthodes suscitant une réponse immunitaire au Streptococcus pneumoniae, et plus particulièrement: sur des polypeptides immunogènes PcpA contenant des fragments de PcpA et leurs invariants, sur des acides nucléiques codant pour lesdits polypeptides; sur des méthodes d'élaboration et d'utilisation desdits polypeptides immunogènes; sur une méthode de diagnostic des infections par les pneumocoques (par exemple la pneumonie) en prélevant un échantillon du patient et en détectant un ou plusieurs antigènes de pneumocoques sélectivement exprimés pendant l'invasion (par exemple le PcpA ou ses fragments).

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