Diagnosis and monitoring of diseases

Details Diagnosis and monitoring of diseases Diagnosis and monitoring of diseases

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A01N 1/00 (2006.01) A01N 1/02 (2006.01) A01N 37/18 (2006.01) A61B 1/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) G01N 33/48 (2006.01) G01N 33/483 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2500652

The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease- associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer~s disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention.

L'invention concerne le diagnostic et le contrôle de maladies et d'états au moyen de marqueurs de quantification, y compris des produits de dégradation de protéines associées à la maladie, telles que des dikétopipérazines composées de deux acides aminés à terminaison N ou des deux acides aminés à terminaison C de ces protéines. Ces méthodes sont utiles pour diagnostiquer ou contrôler différentes maladies, y compris la sclérose multiple, la maladie d'Alzheimer et l'ischémie. Elle concerne, de plus, des partenaires de liaison spécifiques pour ces marqueurs, des compositions et des trousses servant à mettre en application ces méthodes.

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