Diagnosis and prognosis of infectious diesease clinical...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2586374

The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

La présente invention concerne un ensemble spécifique de marqueurs d'expression génique issus des leucocytes du sang périphérique qui indiquent une réponse d'hôte à l'exposition, la réaction et la guérison d'infections par des pathogènes infectieux. L'invention se rapporte en outre à des procédés qui permettent d'identifier l'ensemble spécifique de marqueurs d'expression génique précité, à des procédés qui permettent de surveiller la progression de la maladie et le traitement d'infections par des pathogènes infectieux, et à des procédés qui permettent de diagnostiquer une infection par un pathogène infectieux et d'identifier le pathogène impliqué.

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