Diagnosis and treatment methods related to aging (8a)

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2531420

Mouse genes differentially expressed in comparisons of gene expression in growth hormone receptor/binding protein gene-disrupted mouse livers and normal mouse livers have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against faster-than-normal biological aging, or to achieve slower- than-normal biological aging. The human molecules may also be used as markers of biological aging, to retard biological aging, or to treat age-related diseases.

L'invention se rapporte à l'expression différentielle des gènes de souris lors de comparaisons de l'expression dans les foies de souris porteuses d'une disruption du gène de la protéine de liaison récepteur/hormone de croissance et dans les foies de souris normales, ainsi qu'à l'identification des protéines et gènes correspondants chez l'homme. Les molécules humaines, ou les antagonistes de celle-ci peuvent être utilisées pour la protection contre un vieillissement biologique plus rapide que la normale, ou pour produire un vieillissement retardé par rapport à la normale. Les molécules humaines peuvent également servir de marqueurs du vieillissement biologique, ou être utilisées pour retarder le vieillissement biologique ou pour traiter les pathologies liées à l'âge.

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