Diagnosis and treatment of a disorder of the...

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 31/505 (2006.01) G01N 33/53 (2006.01) G01N 33/60 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2025398

ABSTRACT DIAGNOSIS AND TREATMENT OF A DISORDER OF THE GASTROINTESTINAL TRACT Cyproheptadine (4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-1- methylpiperidine) for the treatment of non-ulcerative dyspepsia (NUD), more particularly NUD which is characterised by dysfunction of central 5-HT 1A receptors. Dysfunction of the central 5-HT 1A receptors can be diagnosed by an azaspirodecanedione-induced prolactin response which is distinguishable from that observed in a subject with peptic ulcer disease and/or inflammatory bowel disease. A suitable azaspirodecanedione for inducing the prolactin response is buspirone.

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