Diagnosis and treatment of alzheimer's disease

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/30 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A01K 67/027 (2006.01)

Patent

CA 2587601

This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream signaling molecules. The invention further relates to methods for the treatment of AD by administering an insulin agonist and an insulin-like growth factor agonist. The invention additionally provides an animal model of AD and methods of screening for agents useful in the treatment, amelioration, or prevention of AD.

Cette invention concerne des méthodes de diagnostic de la maladie d'Alzheimer (AD) par détermination du niveau ou de la fonction de l'insuline, de facteurs de croissance insulinoïdes, leurs récepteurs et/ou leurs molécules de signalisation aval. L'invention concerne également des méthodes de traitement de la maladie d'Alzheimer par administration d'un agoniste de l'insuline et d'un agoniste du facteur de croissance insulinoïde. L'invention concerne aussi un cobaye animal de la maladie d'Alzheimer et des méthodes de criblage d'agents utiles dans le traitement, l'amélioration ou la prévention de la maladie d'Alzheimer.

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