Diagnosis and treatment of cancer

Details Diagnosis and treatment of cancer Diagnosis and treatment of cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2451218

The invention is based on the elucidation of a mechanism by which HPV promotes oncogenesis and provides a methods of diagnosing malignant tumors and methods of preventing the development of malignancies or inhibiting tumor growth. A method for diagnosing a neoplasm in a mammal is carried out by measuring the level of helicase-like transcription factor (HLTF) in tissue of the mammal. An increase in the level of HLTF in the tissue compared to the level in a normal control tissue indicates the presence of a neoplasm in the tissue.

L'objectif de cette invention est d'éclairer le mécanisme selon lequel le papillomavirus (HPV) entraîne l'oncogenèse. Elle porte par ailleurs sur des méthodes de diagnostic des tumeurs malignes ainsi que sur des méthodes de prévention du développement de tumeurs malignes ou d'inhibition de croissance tumorale. Une méthode de diagnostic des tumeurs chez un mammifère consiste à mesurer le taux de <= helicase-like transcription factor >= (HLTF) dans ses tissus. L'augmentation du taux de HLTF dans ces tissus par rapport au même taux dans des tissus témoins normaux indique la présence de tumeurs.

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