Diagnosis and treatment of cancer using anti-desmoglein-3...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61P 1/04 (2006.01) A61P 1/18 (2006.01) A61P 11/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) G01N 33/574 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2658050

Disclosed is a method for the diagnosis of cancer, which is characterized by detecting a DSG3 protein. It is found that the increase in the expression level of DSG3 is observed in lung cancer highly frequently at a gene or protein level. The method can be effected by using an antibody capable of recognizing a DSG3 protein. Also disclosed are a pharmaceutical composition, a cell proliferation inhibitor and an anti-cancer agent, each comprising an antibody capable of binding to DSG3 as an active ingredient. Further disclosed a method for inducing the cytopathy in a DSG3-expressing cell and a method for inhibiting the proliferation of a DSG3-expressing cell, each by contacting the DSG3-expressing cell with an antibody capable of binding to DSG3.

La présente invention concerne un procédé pour le diagnostic du cancer, qui est caractérisé par la détection d'une protéine DSG3. On a trouvé que l'augmentation du niveau d'expression de DSG3 est observée dans le cancer du poumon de manière extrêmement fréquente au niveau d'un gène ou d'une protéine. Le procédé peut être réalisé en utilisant un anticorps pouvant reconnaître une protéine DSG3. L'invention concerne également une composition pharmaceutique, un inhibiteur de la prolifération cellulaire et un agent anticancéreux, chacun comprenant un anticorps pouvant se lier à DSG3 sous forme d'un ingrédient actif. La présente invention concerne en outre un procédé destiné à induire la cytopathie dans une cellule exprimant DSG3 et un procédé destiné à inhiber la prolifération d'une cellule exprimant DSG3, chacun par la mise en contact de la cellule exprimant DSG3 avec un anticorps pouvant se lier à DSG3.

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