Diagnosis and treatment of cancer using anti-ereg antibody

Details Diagnosis and treatment of cancer using anti-ereg antibody Diagnosis and treatment of cancer using anti-ereg antibody

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 51/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 16/22 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2665528

Disclosed is a method for diagnosis of cancer, which is characterized by detecting an epiregulin (EREG) protein. It is found that the expression of an EREG is enhanced at a vary high frequency in a gene level or a protein level in gastrointestinal cancer, pulmonary adenocarcinoma, pancreatic cancer, gastric cancer or renal cancer. In the diagnosis or treatment of cancer, an antibody recognizing the EREG protein is used. Also disclosed are a pharmaceutical composition, a cell proliferation inhibitor and an anti-cancer agent, each comprising an antibody capable of binding to an EREG as an active ingredient. Further disclosed is a method for inducing cytopathy in an EREG-expressing cell or inhibiting the proliferation of an EREG-expressing cell, by contacting the EREG-expressing cell with an antibody capable of binding to an EREG.

L'invention concerne un procédé pour le diagnostic du cancer, qui est caractérisé par la détection d'une protéine épiréguline (EREG). Il a été trouvé que l'expression d'une EREG est augmentée à une fréquence très élevée au niveau du gène ou au niveau des protéines lors du cancer gastro-intestinal, de l'adénocarcinome pulmonaire, du cancer du pancréas, du cancer de l'estomac ou due cancer des reins. Dans le diagnostic ou le traitement du cancer, un anticorps reconnaissant la protéine EREG est utilisé. L'invention décrit également une composition pharmaceutique, un inhibiteur de la prolifération cellulaire et un agent anticancéreux, chacun comprenant un anticorps capable de se lier à une EREG en tant qu'ingrédient actif. L'invention concerne, en outre, un procédé d'induction d'une cytopathie dans une cellule exprimant l'EREG ou l'inhibition de la prolifération d'une cellule exprimant l'EREG, par la mise en contact de la cellule exprimant l'EREG avec un anticorps capable de se lier à une EREG.

Affiliated with

Also associated with

Rating

Diagnosis and treatment of cancer using anti-ereg antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis and treatment of cancer using anti-ereg antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis and treatment of cancer using anti-ereg antibody will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1506962