C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2748990
With dedicated research, the present inventors discovered that not only the LGR7 gene but also the LGR7 protein are highly expressed in clear cell adenocarcinoma cells of ovarian cancer. Furthermore, the present inventors found that anti-LGR7 antibodies have antibody-dependent cell-mediated cytotoxicity (ADCC) activity and complement- dependent cytotoxicity (CDC) activity against LGR7-expressing cells. From the above findings, the present inventors discovered that the anti-LGR7 antibodies are useful for diagnosis, prevention, and treatment of primary and metastatic ovarian clear cell adenocarcinoma.
Des études extensives ont été faites, et il est trouvé qu'un gène pour la protéine LGR7 ainsi que la protéine elle-même sont fortement exprimés dans les cellules d'un adénocarcinome à cellules claires qui est un type de cancer des ovaires. Il est également trouvé qu'un anticorps anti-LGR7 a une activité cytotoxique à médiation cellulaire dépendante des anticorps (ADCC) et une activité cytotoxique à médiation cellulaire dépendante du complément (CDC) contre les cellules exprimant LGR7. Sur la base de ces découvertes, il est trouvé qu'un anticorps anti-LGR7 est utile pour le diagnostic, la prévention et le traitement d'un adénocarcinome à cellules claires primaire ou métastatique.
Aburatani Hiroyuki
Funahashi Shinichi
Uehara Yuriko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Forerunner Pharma Research Co. Ltd.
The University Of Tokyo
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