C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2072356
ABSTRACT OF THE DISCLOSURE Methods for diagnosing the onset or monitoring of the course of a disease comprising obtaining a T-cell nucleic acid or polypeptide test sample from an animal and detecting in such test sample a first target nucleic acid or polypeptide sequence correlated with the disease. The first target nucleic acid or sequence corresponds to a DNA sequence encoding the variable region of a chain of a T- cell receptor. The first target polypeptide sequence corresponds to a variable region of a chain of a T-cell antigen receptor. Methods for treating an animal afflicted with a disease correlated with a T-cell clone containing a specific variable region. The method comprises treating the animal with at least one antibody which is reactive with the specific variable region of the T-cell clone. Antibodies for detecting or treating a disease correlated with at least one T-cell clone containing a specific variable region wherein said antibody is specific for said variable region.
Beall Stevens S.
Concannon Patrick
Hood Leroy E.
Urban James L.
Zaller Dennis M.
California Institute Of Technology
Osler Hoskin & Harcourt Llp
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