A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61K 31/13 (2006.01) A61K 31/195 (2006.01) A61K 31/235 (2006.01) A61K 31/24 (2006.01) A61K 31/35 (2006.01) A61P 31/22 (2006.01) C07D 493/06 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2410252
Methods and compositions for treating or preventing virus infections by interfering with the activity or function of Ras, the Ras pathway, the ERK pathway, MEK1/2, PKR or eIF-2.alpha., includes the use of agents which inhibit Ras or otherwise modulate anti-PKR activity. Also, a method of diagnosing such virus infections includes the use of cell lines that have an activated Ras pathway, including cell lines which have been transformed with a gene that activates the Ras pathway. The virus infections may be herpes virus infections and HSV-1 or HSV-2 infections in particular.
L'invention concerne des méthodes et des compositions pour le traitement ou la prévention d'infections virales, par modification de l'activité ou de la fonction de Ras, de la voie Ras, de la voie ERK, de ou MEK1/2, PKR ou elF-2.alpha.. Lesdites méthodes consistent à utiliser des agents qui inhibent Ras ou modulent l'activité anti-PKR. Par ailleurs, l'invention porte sur une méthode de diagnostic desdites infections virales, qui consistent à utiliser des lignées cellulaires ayant une voie Ras activée, dont des lignées cellulaires ayant été transformées à l'aide d'un gène qui active la voie Ras. Lesdites infections virales peuvent être des infections herpétiques et notamment des infections à HSV1 ou HSV2.
Farassati Faris
Lee Patrick W. K.
Yang An-Dao
Bennett Jones Llp
Farassati Faris
Lee Patrick W. K.
Yang An-Dao
LandOfFree
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