Diagnosis and treatment of malignant neoplasms

Details Diagnosis and treatment of malignant neoplasms Diagnosis and treatment of malignant neoplasms

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 16/40 (2006.01) C12Q 1/26 (2006.01) G01N 33/543 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01)

Patent

CA 2390374

The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH. Methods of inhibiting tumor growth by contacting a tumor cell with an HAAH antisense nucleic acid are also included.

L'invention concerne une méthode permettant de diagnostiquer une tumeur maligne chez un mammifère, consistant à mettre un liquide biologique du mammifère en contact avec un anticorps qui se fixe sur un polypeptide humain d'aspartyl (asparaginyl) bêta-hydroxylase (HAAH), et des méthodes de traitement de tumeurs malignes par inhibition de l'HAAH. L'invention concerne également des méthodes permettant l'inhibition de la croissance tumorale, consistant à mettre une cellule tumorale en contact avec un acide nucléique antisens HAAH.

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