Diagnosis and treatment of micobacterial infections

Details Diagnosis and treatment of micobacterial infections Diagnosis and treatment of micobacterial infections

G - Physics

01

N

G01N 33/569 (2006.01) C07K 4/04 (2006.01) C07K 14/35 (2006.01)

Patent

CA 2543078

The invention provides a method for detecting infection of an animal with a micro-organism that causes a slow progressive disease, comprising providing said animal with a protein of said micro-organism, or a functional part, derivative and/or analogue thereof, and measuring an immune response of said animal directed against said micro-organism. With a method of the invention, diagnosis during early stages of an infection has become possible. In one aspect said micro-organism comprises Mycobacterium aviumsubspecies paratuberculosis. Preferably, said protein comprises a surface-associated protein. Peptides comprising B-cell epitopes of M.avium ssp paratuberculosis heat shock protein 70, nucleic acid molecules encoding such peptides and diagnostic kits comprising a peptide and/or nucleic acid molecule of the invention are also herewith provided.

La présente invention a trait à un procédé pour la détection d'infection chez un animal avec un micro-organisme qui entraîne une maladie à évolution lente, comprenant l'administration au dit animal d'une protéine dudit micro-organisme, ou une partie fonctionnelle, un dérivé et/ou un analogue de celui-ci, et la mesure d'une réponse immunitaire dudit animal dirigée contre ledit micro-organisme. Le procédé de la présente invention permet le diagnostic précoce d'une infection. Dans un mode de réalisation, ledit micro-organisme comporte le Mycobycterium avium subspecies paratuberculosis. De préférence, ladite protéine comporte une protéine liée à la surface. L'invention a également trait à des peptides comportant des épitopes de cellule B de la protéine de choc thermique 70 de M.avium ssp paratuberculosis, à des molécules d'acides nucléiques codant pour de tels peptides et à des trousses de diagnostic comportant un peptide et/ou une molécule d'acides nucléiques de l'invention

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