C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01N 43/04 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2278465
The invention provides methods and kits for diagnosing myocardial failure in a human. One method comprises obtaining a sample of myocardial tissue from a ventricle of the heart of the human; quantitating the expression of alpha-myosin heavy chain (alpha-MHC), beta-myosin heavy chain (beta-MHC), or both in the sample; and determining by statistical analysis if the expression of alpha-MHC or beta--MHC, or both in the sample is significantly different than their expression in human ventricular myocardial tissue. The invention also comprises a method of treating myocardial failure in a human.
L'invention concerne un procédé permettant de diagnostiquer une défaillance myocardique chez un être humain. Le procédé comporte les étapes consistant à obtenir un échantillon de tissu myocardique provenant d'un ventricule de coeur humain; quantifier l'expression de chaînes lourdes d'alpha-myosine (alpha-MHC), de chaînes lourdes de bêta-myosine (bêta-MHC), ou des deux à la fois dans l'échantillon; et déterminer par analyse statistique si l'expression d'alpha-MHC ou de bêta-MHC, ou des deux ensemble dans l'échantillon est significativement différente de leur expression dans un tissu myocardique ventriculaire humain normal.
Bristow Michael R.
Leinwand Leslie A.
Minobe Wayne
Nakao Koichi
Gowling Lafleur Henderson Llp
The Regents Of The University Of Colorado A. Body Corporate
University Technology Corporation
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