Diagnosis and treatment of siglec-6 associated diseases

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2570034

The present invention relates to agonists, antagonists, and other molecules that specifically bind SIGLEC-6 on mast cells, their use in the treatment of asthma and other SIGLEC-6 mediated diseases or disorders, methods of diagnosing such diseases or disorders, and methods of screening for candidate compounds capable of modulating SIGLEC-6 activity in mast cells. The present invention also relates to the diagnosis and treatment of B-cell related disorders using compounds that bind and/or modulate SIGLEC-6.

La présente invention concerne des agonistes, des antagonistes et d'autres molécules se liant spécifiquement à SIGLEC-6 sur des mastocytes, leur utilisation dans le traitement de l'asthme et d'autres maladies ou troubles médiés par SIGLEC-6, des méthodes destinées à diagnostiquer ces maladies ou ces troubles, ainsi que des méthodes de criblage de composés candidats capables de moduler l'activité de SIGLEC-6 dans les mastocytes. La présente invention concerne également le diagnostic et le traitement de troubles associés aux cellules B au moyen de composés se liant à SIGLEC-6 ou la modulant.

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