Diagnosis and treatment of tuberous sclerosis

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/42 (2006.01) A61K 31/436 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2495085

The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions for treating cancers mediated by TSC signaling disorders.

L'invention concerne des compositions et des procédés permettant d'identifier des anomalies propres aux trajets de signalisation de la sclérose tubéreuse. En particulier, l'invention concerne des procédés relatifs au diagnostic et au traitement de troubles comme la sclérose tubéreuse, engendrés par des mutations dans les gènes de cette sclérose. L'invention concerne également des procédés et des compositions permettant de traiter les cancers dont la médiation est assurée par les anomalies de signalisation considérées.

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