Diagnosis by sensing volatile components

Details Diagnosis by sensing volatile components Diagnosis by sensing volatile components

G - Physics

01

N

G01N 33/497 (2006.01) C12M 1/34 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) G01N 33/50 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2444052

A state, particularly a disease state, associated with the production of volatiles is detected by passing a sample containing the volatiles to a single sensor. This may be a semiconductor gas sensor element or a surface acoustic wave device. This provides an output signal, e.g. in the form of a tailing peak. A plurality of characteristics of the signal (e.g. peak height and maximum positive gradient) are measured to characterise the sample and hence the underlying state. For example we can discriminate between urine samples which are (a) infected with proteus, (b) infected with E. coli or (c) uninfected.

Selon l'invention, un état, en particulier un état pathologique, associé à la production de composants volatils est détecté par exposition d'un échantillon contenant lesdits composants volatils à un capteur individuel. Ledit capteur peut se présenter sous la forme d'un élément capteur de gaz à semi-conducteurs ou d'un dispositif de traitement des ondes acoustiques de surface. Le signal de sortie obtenu se présente par exemple sous la forme d'une pointe de traînage. Une pluralité de caractéristiques du signal (par ex. hauteur de pointe et gradient positif maximal) est mesurée afin de caractériser l'échantillon et donc l'état correspondant. Il est par exemple possible de différencier des échantillons d'urine (a) infectée par proteus, (b) E. coli, (c) non infectée.

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