Diagnosis of (a risk of) disease and monitoring of therapy

Details Diagnosis of (a risk of) disease and monitoring of therapy Diagnosis of (a risk of) disease and monitoring of therapy

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2558604

The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from said individual comprises an expression product of AC133 in an amount that is indicative for said disease or for the treatment thereof. Said amount is preferably quantified and compared with a reference value. In one aspect said amount is compared with an amount of said expression product present in a sample that was obtained from said individual before said treatment. A use of a nucleic acid molecule comprising at least part of a sequence of AC133 or an analogue thereof for monitoring a treatment of an individual suffering from a disease is also provided, as well as a diagnostic kit comprising such nucleic acid molecule.

L'invention porte sur un procédé d'identification d'un prélèvement effectué sur un patient souffrant ou risquant de souffrir d'une maladie. L'invention porte également sur une méthode de suivi du traitement d'un patient souffrant d'une maladie, consistant à déterminer si ledit prélèvement comprend un produit d'expression de l'AC133 en une quantité révélatrice de ladite maladie, ou nécessitant son traitement. Dans une exécution, on compare ladite quantité avec un prélèvement effectué sur ledit patient avant le traitement. L'invention porte en outre sur l'utilisation d'une molécule d'acide nucléique comprenant au moins partie d'une séquence de l'AC133 ou d'un de ses analogues pour suivre le traitement d'un patient souffrant d'une maladie, et sur une trousse de diagnostic comportant ladite molécule.

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