C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2525646
Methods of diagnosis of abnormal blood conditions associated with an increased risk of bleeding are described. Subjects homozygous or heterozygous for the GPVIb allele are at considered to be at increased risk of bleeding. Kits for carrying out the methods of diagnosis, and use of the methods and kits for determining the GPVI allelotype of subjects in need of surgery, with a low platelet count, with an acquired bleeding disorder, on blood thinning drugs, or of blood donors is also described.
La présente invention se rapporte à des méthodes permettant de diagnostiquer des conditions sanguines anormales associées à un risque accru de saignement. Les sujets homozygotes ou hétérozygotes pour l'allèle GPVI?b¿ sont considérés comme étant des sujets présentant un risque accru de saignement. L'invention se rapporte également à des trousses permettant la mise en oeuvre desdites méthodes de diagnostic, ainsi qu'à l'utilisation de ces méthodes et de ces trousses pour déterminer l'allelotype GPVI de patients nécessitant une intervention chirurgicale, ayant une faible numération des thrombocytes, présentant un trouble du saignement acquis, suivant un traitement à base d'anticoagulants ou de donneurs de sang.
Farndale Richard Willam
Ouwehand Willem
Smethurst Peter Alexander
Cambridge Enterprise Limited
Sim & Mcburney
The Chancellor Masters And Scholars Of The University Of Cambridge
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