Diagnosis of carcinomas

Details Diagnosis of carcinomas Diagnosis of carcinomas

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2459077

The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.

L'invention concerne des compositions et des procédés pour la détection d'un état pathologique malin, et, en particulier, la découverte de formes solubles et de surface cellulaire de polypeptides HE4a, y compris le HE4a qui est surexprimé dans les carcinomes de l'ovaire. L'invention concerne en particulier une séquence d'acide nucléique codant les HE4a, ainsi qu'un procédé de criblage permettant de déterminer la présence d'un état pathologique malin chez un sujet par détection de la réactivité d'un anticorps spécifique à un polypeptide HE4a vis-à-vis d'une molécule apparaissant naturellement sous la forme soluble et/ou de surface cellulaire, dans un échantillon prélevé chez un tel sujet et par criblage par hybridation à l'aide d'une séquence nucléotidique de HE4a, ainsi que d'autres avantages associés.

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