Diagnosis of collagen ix destruction

Details Diagnosis of collagen ix destruction Diagnosis of collagen ix destruction

G - Physics

01

N

G01N 33/68 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2679321

A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the neoepitopes were created by the cleavages and an epitope in the cleaved N-terminal part of the NC4 domain unique to collagen IX. A diagnostic kit and antibodies useful in carrying out such methods are also presented.

L'invention concerne un procédé permettant de détecter ou de surveiller la présence de fragments protéiniques clivés au niveau de nouveaux sites de clivage situés près de la partie N-terminale de la chaîne .alpha.1 du collagène IX; près de la partie C-terminale du domaine NC4; et au niveau du domaine COL3, près du domaine NC3. Des anticorps anti-néoépitopes créés par clivages sont dirigés contre des néoépitopes et contre un épitope de la partie N-terminale du domaine NC4 unique au collagène IX. L'invention concerne également un kit de diagnostic et des anticorps utiles pour mettre en oeuvre les procédés de l'invention.

Affiliated with

Also associated with

Rating

Diagnosis of collagen ix destruction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis of collagen ix destruction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis of collagen ix destruction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1746047