Diagnosis of dementia utilizing thrombospondin

Details Diagnosis of dementia utilizing thrombospondin Diagnosis of dementia utilizing thrombospondin

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2473866

A method for diagnosing various forms of dementia, including MCI, and Alzheimer's disease (AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically thrombospondin, in bodily fluid, preferably blood or a blood product. The detection is by an immunoassay incorporating an antibody specific to thrombospondin, or alternatively an autoantibody to a thrombospondin antibody.

L'invention porte sur un procédé de diagnostic de différentes formes de la démence telle que la déficience cognitive légère et la maladie d'Alzheimer. Le procédé consiste à détecter directement la présence d'un marqueur biochimique, notamment la thrombospondine, dans un fluide biologique, de préférence le sang ou un produit sanguin. Cette détection s'effectue par dosage immunologique comprenant un anticorps spécifique de la thrombospondine ou alternativement un auto-anticorps contre un anticorps de la thrombospondine.

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