C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2521757
Mouse genes differentially expressed in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic liver by gene chip analysis have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequelae.
On a identifié des gènes de souris à expression différentielle dans des comparaisons entre foie normal et foie hyperinsulinique, entre foie hyperinsulinique et foie diabétique de type, et entre foie normal et foie diabétique de type 2 par l'analyse de puce à ADN, tout comme des gènes et des protéines humains correspondants. Les molécules humaines, ou leurs antagonistes, peuvent être utilisées pour la protection contre l'hyperinsulinisme ou le diabète de type 2, ou leurs séquelles.
Boyce Keith S.
Kelder Bruce
Kopchick John J.
Kriete Andres
Icoria Inc.
Ohio University
Smart & Biggar
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