Diagnosis of liver pathology through assessment of protein...

Details Diagnosis of liver pathology through assessment of protein... Diagnosis of liver pathology through assessment of protein...

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/576 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2607285

Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.

L'invention concerne des méthodes permettant de diagnostiquer les maladies du foie chez un sujet susceptible de présenter une telle maladie. Les méthodes consistent à détecter de manière quantifiable la glycosylation et, d'une manière plus spécifique, la fucosylation, sur des protéines issues de fluides biologiques, et de comparer la glycosylation détectée avec des valeurs de référence pour la glycosylation de ces protéines dans des états sains ou malades.

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