Diagnosis of melanoma and solar lentigo by nucleic acid...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G06F 19/20 (2011.01) C40B 30/04 (2006.01) C40B 40/02 (2006.01) C40B 40/06 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2724322

The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

La présente invention concerne des procédés permettant de diagnostiquer un mélanome et/ou un lentigo solaire chez un sujet par l'analyse de molécules d'acides nucléiques prélevées sur ce sujet. La présente invention concerne aussi des procédés permettant de distinguer un mélanome de lentigo solaire et/ou d'un naevus dysplasique et/ou de peau pigmentée normale. Des procédés consistent à analyser l'expression ou des mutations dans des échantillons épidermiques, d'un ou de plusieurs marqueurs de la peau. Ces procédés peuvent comprendre l'utilisation d'une micropuce pour analyser des profils de gène ou de protéine d'un échantillon.

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