Diagnosis of melanoma by nucleic acid analysis

C - Chemistry – Metallurgy – 12 – Q

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Details

C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2686212

The present invention provides methods for diagnosing melanoma in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.

La présente invention concerne des procédés de diagnostic du mélanome chez un sujet en analysant les molécules d'acides nucléiques prélevées chez le sujet. L'invention concerne également des procédés permettant de distinguer un mélanome d'un nævus dysplasique et/ou d'une peau pigmentée normale. Les procédés incluent l'analyse de l'expression ou des mutations d'un ou plusieurs marqueurs cutanés dans des échantillons épidermiques. Les procédés peuvent inclure l'utilisation d'une micropuce pour analyser le profil des gènes ou des protéines dans un échantillon.

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