C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2181062
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts- 1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.
L'invention porte sur le diagnostic de tumeurs malignes par détection de l'ARNm <u>mts-1</u> ou de la protéine <u>mts-1</u> codés par le gène <u>mts-1</u>. Elle consiste à utiliser l'ADN <u>mts-1</u> de recombinaison et les anticorps dirigés contre la protéine <u>mts-1</u> pour diagnostiquer le potentiel métastasique de plusieurs types de cellules tumorales dont p. ex. celles de la thyroïde, de l'épithélium, du poumon, du foie, et du rein. Elle s'applique également aux lignées de cellules mammaliennes et aux tumeurs à faible ou fort potentiel métastasique ayant été formées pour servir de modèle en vue de la sélection <u>in </u> <u>vitro</u> ou <u>in</u> <u>vivo</u> de médicaments antimétastasiques.
Lukanidin Eugene
Zain Sayeeda
Mcfadden Fincham
Research Corporation Technologies Inc.
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