Diagnosis of prostate cancer

Details Diagnosis of prostate cancer Diagnosis of prostate cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2588705

The present invention provides a method for determining the presence of prostate cancer in a subject which method comprises determining the level of expression of one or more markers in a blood sample from the subject, wherein said one or more markers comprise at least one of EM, c-met, pRB, EZH2, e-cad, CAXII, CAIX, HIF-1.alpha., Jagged, PIM- 1, hepsin, RECK, Clusterin, MMP9, MTSP- 1, MMP24, MMP15, IGFBP-2, IGFBP-3, E2F4, caveolin, EF-1A, Kallikrein 2, Kallikrein 3 and PSGR.

Cette invention concerne un procédé permettant de déterminer la présence d'un cancer de la prostate chez un sujet, lequel procédé consiste à déterminer le niveau d'expression d'un ou plusieurs marqueurs dans un échantillon sanguin prélevé sur le sujet, le ou les marqueurs comprenant au moins un des éléments suivants: E2F3, c-met, pRB, EZH2, e-cad, CAXII, CAIX, HIF-1.alpha., Jagged, PIM- 1, hepsine, RECK, Clusterine, MMP9, MTSP-1, MMP24, MMP15, IGFBP-2, IGFBP-3, E2F4, cavéoline, EF-1A, Kallikréine 2, Kallikréine 3 et PSGR.

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