Diagnosis of recent tuberculosis infection by comparing...

Details Diagnosis of recent tuberculosis infection by comparing... Diagnosis of recent tuberculosis infection by comparing...

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2490172

Method of diagnosing in an individual recent exposure to an agent which is a pathogen, vaccine or any other moiety which induces a cellular response, said method comprising determining in vitro whether the T cells of the individual recognise a protein from said agent having a length of at least 30 amino acids, to a greater extent than one or more peptide epitopes from the agent, a greater extent of recognition of the protein indicating that the individual has recently been exposed to the agent.

L'invention concerne une méthode de diagnostic chez un sujet d'une exposition récente à un agent, tel qu'un pathogène, un vaccin ou un autre fragment induisant une réponse cellulaire. Ladite méthode consiste à déterminer in vitro si les lymphocytes T du sujet reconnaissent une protéine dudit agent, d'une longueur d'au moins 30 aminoacides, dans des proportions plus importantes qu'un ou plusieurs épitopes peptidiques de l'agent, une reconnaissance plus importante de la protéine indiquant que le sujet a été exposé récemment audit agent.

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