Diagnosis of stage or aggressiveness of cancer

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2353546

A method of diagnosing the stage or aggressiveness of cancer and particularly breast and prostate cancer by measuring the deviation of levels of fatty acid binding proteins in mammalian tissue or body fluids from normal levels of fatty acid binding proteins. The invention relates to a family of key proteins called fatty acid binding proteins which are involved in metabolism of AA and other lipids and how they affect the proliferation of cancer cells.

La présente invention concerne une technique de diagnostic de la phase d'évolution ou de l'agressivité de cancers, notamment des cancers du sein et de la prostate. Cette technique utilise une mesure de l'écart par rapport à la normale des niveaux de protéines de liaison d'acides gras des tissus ou fluides anatomiques des mammifères. L'invention concerne également une famille de protéines clés ou "protéines de liaison d'acides gras" qui sont impliquées dans le métabolisme de lipides et notamment de l'acide arachidonique et dans les processus affectant la prolifération des cellules cancéreuses.

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