Diagnosis of susceptibility to cancer and treatment thereof

Details Diagnosis of susceptibility to cancer and treatment thereof Diagnosis of susceptibility to cancer and treatment thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2232241

A method for determining the susceptibility of a patient to cancer comprising the steps (i) obtaining a sample containing nucleic acid derived from the patient; and (ii) contacting the said nucleic acid with a nucleic acid capable of selectively hybridising to the region of human chromosome 10 which region is bounded by DNA defined by the markers D10S541 and D10S215. A nucleic acid capable of selectively hybridising to the region of human chromosome 10 which region is bounded by DNA defined by the markers D10S541 and D10S215 provided that the nucleic acid is not any one of certain YACs, BACs, PACs or ESTs defined herein. Preferably the said nucleic acid is a prostate tumour suppressor gene.

Un procédé pour déterminer la prédisposition d'un patient au cancer consiste (i) à prélever sur celui-ci un échantillon contenant un acide nucléique; et (ii) à mettre en contact ledit acide nucléique avec un acide nucléique susceptible d'hybridation sélective avec la région du chromosome humain 10 délimitée par l'ADN défini par les marqueurs D10S541 et D10S215, à condition que cet acide nucléique ne soit pas l'un quelconque de certains chromosomes artificiels de levure, chromosomes artificiels bactériens, chromosomes artificiels dérivés de P1 ou marqueurs de séquences exprimées définis dans le présent fascicule. Ledit acide nucléique est de préférence un gène suppresseur de la tumeur de la prostate.

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